Supportive Published Papers

Barnes S. Effect of Genistein on In Vitro and in Vivo Models of Cancer. Journal of Nutrition 1995;125:777-793.

Barnes S, Kirk M and Coward L. Isoflavones and Their Conjugates in Soy Food: Extraction Conditions and Analysis by HPLC-Mass Spectrometry. Journal of Agriculture and Food Chemistry 1994;42:2466-74.

Boersma BJ, Barnes S, Kirk M, Wang CC, Smith M, Kim H, Xu J, Patel R and Darley-Usmar VM. Soy Isoflavonoids and Cancer-Metabolism at the Target Site. Mutation Research 2001;480-481:121-127.

Bingham S.A., Atkinson C, Liggins J, Bluck L and Coward A. Phyto-estrogens: Where are we now? British Journal of Nutrition 1998;79:393-406.

Chang HC, Churchwell MI, Delclos KB, Newbold RR and Doerge DR. Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats. Journal of Nutrition 2000;130:1963-1970.

Coldham NG, Howells LC, Santi A, Montesissa C, Langlais C, King LJ, Macpherson DD and Sauer MJ. Biotransformation of Genistein in the Rat: Elucidation of Metabolite Structure by Product Ion Mass Fragmentology. Journal of Steroid Biochemistry and Molecular Biology 1999;70:169-184.

Fotsis T, Pepper M, Adlercreutz H, Hase T, Montesano R and Schweigerer L. Genistein, A Dietary inhibitor of In Vitro Angiogenesis. Journal of Nutrition 1995;125(3):790-797.

Franke A, Custer L, Cerna C and Narala KK. Quantitation of Phytoestrogens in Legumes by HPLC. Journal of Agriculture and Food Chemistry 1994;42:1905-1913.

Freeman C and Parish R. A Rapid Quantitative Assay for the Detection of Mammalian Heparanase Activity. Journal of Biochemistry 1997;325:229-237.

FriedmannY, Viodavsky I, Aingom H, Avlv A, Peretz T, Pecker I and Pappo O. Expression of Heparanase in Normal, Dysplastic and Neoplastic Human Colonic Mucosa and Stroma; Evidence for Its Role in Colonic Tumorigenesis. American Journal of Pathology 2000;157:1167-1175.

Hsieh C, Santell R C, Haslam SZ and Helferich WG. Estrogenic Effects of Genistein on the Growth of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Cells in Vitro and in Vivo. Cancer Research 1998;58:3833-3838.

Izumi T, Piskula M, Osawa S, Obata A, Tobe K, Saito M, Kataoka S, Kubota Y and Kikuchi M. Soy Isoflavone Aglycones are Absorbed Faster and in Higher Amounts than their Glucosides in Humans. Journal of Nutrition 2000;130:1695-1699.

Lamartiniere CA, Moore JB, Brown NM, Thompson R, Hardin MJ and Barnes S. Genistein Suppresses Mammary Cancer in Rats. Carcinogenesis 1995;16(11):12833-2840.

Lamartiniere, CA. Protection Against Breast Cancer with Genistein: A Component of Soy. American Journal of Clinical Nutrition 2000;71(6):1705-1707.

Matsuda S, Miyazaki T, Matsumoto Y, Ohba R, Teramoto Y, Ohta N and Ueda S. Hydrolysis of Isoflavones in Soybean Cooked Syrup By Lactobacillus casei subsp. rhamnosus IFO 3425. Journal of Fermentation and Bioengineering 1992;74: 301-304.

Messina MJ, PerskyV, Setchell KDR and Barnes S. Soy Intake and Cancer Risk: A Review of the in Vitro and in Vivo Data. Nutrition and Cancer 1994;21:113-131.

Nguyen M, Shing Y and Folkman J. Quantitation of Angiogenesis and Antiangiogenesis in the Chick Embryo Chorioallantoic Membrane. Microvascular Research 1994;47:31-40.

Peterson G. Evaluation of the Biochemical Targets of Genistein in Tumor Cells. Journal of Nutrition 1995;125:784-785.

Peterson G and Barnes S. Genistein Inhibition of the Growth of Human Breast Cancer Cells: Independence from Estrogen Receptors and the Multi-Drug Resistance Gene. Biochemical and Biophysical Research Communications 1991;179(1):661-667.

Santell R, Kieu N and Helferich W. Genistein Inhibits Growth of Estrogen-Independent Human Breast Cancer Cells in Culture but Not in Athymic Mice. Journal of Nutrition 2000;130:1665-1669.

Scalbert A and Williamson G. Dietary Intake and Bioavailability of Polyphenols. Journal of Nutrition 2000;130:2073-2085.

Setchell KDR. Phytoestrogens: the Biochemistry, Physiology and Implications for Human Health of Soy Isoflavones. American Journal of Clinical Nutrition 1998;68:1333-146.

Setchell KDR and Cassidy A. Dietary Isoflavones: Biological Effects and Relevance to Human Health. Journal of Nutrition 1999;129:758-767.

Shelnutt SR, Cimino CO, Wiggins PA and Badger TM. Urinary Pharmacokinetics of the Glucuronide and Sulfate Conjugates of Genistein and Daidzein. Cancer Epidemiology, Biomakers & Prevention 2000;9:413-419.

Song T, Barua K, Buseman G and Murphy PA. Soy Isoflavone Analysis: Quality Control and A New Internal Standard. American Journal of Clinical Nutrition 1998;68:1474-1479.

Stahl PD and Touster O. Beta-Glucuronidase of Rat Liver Lysosomes. Journal of Biological Chemistry 1971;245(17):5398-5406.

Wang H and Murphy P. Isoflavone Content in Commercial Soybean Foods. Journal of Agriculture and Food Chemistry 1994;42:1666-1673.

Xu X, Harris K, Wang H, Murphy P and Hendrich S. Bioavailability of Soybean Isoflavones Depends upon Gut Microflora in Women. Journal of Nutrition 1995;125:2307-2315.

Zand RS, Jenkins JA and Diamandis EP. Genistein: A Potent Natural Antiandrogen. Clinical Chemistry 2000;46:887-888.

Zhang Y, Song TT, Cunnick JE, Murphy PA and Hendrich S. Daidzein and Genistein Glucuronides in Vitro are Weakly Estrogenic and Activate Human Natural Killer Cells at Nutrionally Relevant Concentrations. Journal of Nutrition 1999;129:399-405.

Zhou JR, Mukherjee, Gugger ET, Tanaka T, Blackburn G and Clinton SK. Inhibition of Murine Bladder Tumorigenesis By Soy Isoflavones via Alterations in the Cell Cycle, Apotosis, and Angiogenesis. Cancer Research 1998;58:5231-5238.