8. Absorption, metabolism and excretion of GCP
Method: Four male and four female healthy persons were given GCP by 2.0 g of dosage one time oral administration, the whole peripheral blood was taken at the times of 0, 1, 3, 5, 7 and 24 hours after the GCP was taken. The urine was collected at times of 0, 2, 4, 6, 8, and 24 hours after taken. The concentrations of GCP in serum and in urine were detected by HPLC. Soybean extract (SEB, the material of GCP) was taken as a control.
Result: GCP concentration in serum as well increased to the peak 3 hours after GCP was taken, then the peaks went down slowly after 5 to 7 hours. Then they removed to the base line about 24 hours later. The result showed that a higher genistein peak (about 5 times greater than the SBE control) occurred in the GCP intake group, which indicated GCP was well absorbed in the serum.
Fig. 19 Changes of GCP concentration in serum of human being
Fig. 20 Changes of GCP concentration in urine of human being
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